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1. Adam M., Spacek P., Hulejova H., Galianova A., Blahos J. “Postmenopausal osteoporosis. Treatment with calcitonine and a diet rich in cartilage proteins”. Cas Lèk ces. 1996, 135: 74-8.
2. Adam M., Eggersglüss B., Bräumer K. and Schrieber R. “Use of tasteless, Hydrolyzed Collagen and Agent containing the same”. United States Patent nº 5,948,766 (7.09.1999).
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5. Elam, ML. et al. “A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial” J Med Food 00 (0) 2014, 1–8
6. Guillerminet F, Beaupied H, Fabien-Soulé V, Tomé D, Benhamou CL, Roux C, Blais A. « Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study”. Bone. 2010 Mar; 46(3):827-34.
7. Guillerminet F, Fabien-Soulé V, Even PC, Tomé D, Benhamou CL, Roux C, Blais A. “Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice”. Osteoporos Int. 2012 Jul; 23(7):1909-19.
8. Hooshmand, S. et al. “Evidence for Bone Reversal Properties of a Calcium- Collagen Chelate, a Novel Dietary Supplement” J Food Nutr Disor 2013, 2:1.
9. Kim HK, Kim MG, Leem KH “Osteogenic activity of collagen peptide via ERK/MAPK pathway mediated boosting of collagen synthesis and its therapeutic efficacy in osteoporotic bone by back-scattered electron imaging and microarchitecture analysis” Molecules 2013, 18, 15474-15489.
10. Kim HK, Kim MG, Leem KH “Collagen hydrolysates increased osteogenic gene expressions via a MAPK signaling pathway in MG-63 human osteoblasts” Food Funct. 2014 Mar; 5(3): 573-8.
11. König D., Oesser S., Scharla S., Zdzieblik D., Gollhofer A. “Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women—A Randomized Controlled Study” Nutrients 2018, 10, 97.
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13. Leem KH, Lee S, Jang A, Kim HK. “Porcine skin gelatin hydrolysate promotes longitudinal bone growth in adolescent rats.” J Med Food. 2013 May; 16(5): 447-53.
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15. Liu, J. et al “Combined Oral Administration of Bovine Collagen Peptides with Calcium Citrate Inhibits Bone Loss in Ovariectomized Rats”. PLOS ONE. 2015 Aug 10;10(8):e0135019.
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a. Anti-vieillissement

1. Asserin J., Lati E., Shioya T., Prawitt J. (2015) “The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials” J. of Cosmetic Dermatology, 0, 1–11.
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4. Campos, Patrícia Maia, et al., (2015) “An oral supplementation based on hydrolyzed collagen and vitamins improves skin elasticity and dermis echogenicity: a clinical placebo-controlled study”. Clin Pharmacol Biopharm 4: 142.
5. Gimenez A, Conesa A, Benito P. “Effect of oral ingestion of Hydrolyzed Collagen on postmenopausal women skin wrinkle – A pilot study”. Octubre 2007.
6. Koyama Y., Sakashita A., Kuwaba K., Kusubata M. “Effects of oral ingestion of collagen peptide on the skin.” Fragr J. 2006; 34 (6): 82-85.
7. Matsuda, N., Koyama, Y-I., Hosaka, Y., Ueda, H., Watanabe, T., Araya, S., Irie, S. and Takehana, K. 2006. “Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis”. Journal of nutritional science and vitaminology. 52: 211-215.
8. Matsumoto, H., Ohara, H., Ito, K., Nakamura, Y. and Takahashi, S. 2006. “Clinical effects of fish type I collagen hydrolysate on skin properties”. ITE Letters on batteries, new Technologies and medicine, 7(4):386-390.
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11. Ohara H, Ito K, Iida H, Matsumoto H. “Improvement in the moisture content of the stratum corneum following 4 weeks of collagen hydrolysate ingestion“. Nippon Shokuhin Kogaku Kaishi 2009; 56: 137-45.
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14. Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. “Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study”. Skin Pharmacol Physiol 2014; 27(1): 47-55.
15. Schunck M., Zague V., Oesser S., and Proksch E. “Dietary Supplementation with Specific Collagen Peptides has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology” J Med Food 18 (12) 2015, 1340–1348.
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19. Sumida, E., Hirota, A., Kuwaba, K., Kusubata, M., Koyama, Y., Araya, T. Irie, S. and Kasugai, S. 2004. “The effect of oral ingestion of collagen peptide on skin hydration and biochemical data of blood”. Journal of nutritional food, 7(3): 45-52.
20. Zague, V. “A new view concerning the effects of collagen hydrolysate intake on skin properties” Arch Dermatol Res. 2008 Oct;300(9):479-83.
21. Zague V, de Freitas V, da Costa Rosa M, de Castro GÁ, Jaeger RG, Machado-Santelli GM. “Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity”. J Med Food. 2011 Jun; 14(6):618-24.
22. Zague, V. et al “Collagen peptides modulate the metabolism of extracellular matrix by human dermal fibroblasts derived from sun-protected and sun-exposed body sites”. Cell Biol Int. 2018 Jan;42(1):95-104.

b. Plaies et ulcères de pression

1. Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. “Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: A randomized controlled trial”. Adv Skin Wound Care. 2006;19:92-96.
2. Nishikimi, A. et al. “Collagen-derived peptides modulate CD4. T-cell differentiation and suppress allergic responses in mice” Immunity, Inflammation and Disease 2018 Jun;6(2):245-255.
3. Okawa T, Yamaguchi Y, Takada S, Sakai Y, Numata N, Nakamura F, Nagashima Y, Ikezawa Z, Aihara M. “Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model”. Journal of Dermatological Science 66 (2012) 136–143.
4. Sugihara F., Inoue N., Sriraam V.T. “The ingestion of bioactive collagen hydrolysate enhanced pressure ulcer healing in a randomized double-blind placebo-controlled clinical study” January 2015
5. Tanaka M, Koyama Y, Nomura Y. “Effects of collagen peptide ingestion on UV-B-induced skin damage”. Biosci Biotechnol Biochem. 2009, 73 (4): 930-932.
6. Wang, J. et al., “Oral administration of marine collagen peptides prepared from chum salmon (Oncorhynchus keta) improves wound healing following cesarean section in rats” Food & Nutrition Research 2015, 59: 26411.
7. Yamanaka H., Okada S., Sanada H., “A multicenter, randomized, controlled study of the use of nutritional supplements containing collagen peptides to facilitate the healing of pressure ulcers” Journal of Nutrition & Intermediary Metabolism 8 (2017) 51-59.
8. Zhang, Z. et al., “Oral administration of skin gelatin isolated from Chum Salmon (Oncorhynchus keta) enhances wound healing in diabetic rats” Mar. Drugs 2011, 9, 696-711.

1. Minaguchi, J. et al “Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in Achilles tendon”. J Nutr Sci Vitaminol (Tokyo). 2005 Jun;51(3):169-74.
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3. Weh L., Petau C. “Change in the Properties of Tissue through the Administration of Gelatine. A Biomechanica Pilot Study”. Extracta orthopaedica. 2001; 4: 12-16.

1. Gronemann ST, Ribel-Madsen S, Bartels EM, Danneskiold-Samsoe B, Bliddal H. 2004. ”Collagen and muscle pathology in fibromyalgia patients”. Rheumatology. 43: 27-31.
2. Olson GB, Savage S, Olson J. 2000. “The effects of collagen hydrolysate on symptoms of chronic fibromyalgia and tempomandibular joint pain”. Cranio, 18(2): 135-41.
3. Sprott H, Muller A, Heine H. 1998.“Collagen cross-links in fibromyalgia syndrome”. Z.Rheumatol. 57 Suppl 2:52-5.
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1. Hays NP, Kim H, Wells AM, Kajkenova O, Evans WJ. “Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older women”. J Am Diet Assoc. 2009 Jun;109(6):1082-7.
2. Zdzieblik D., Oesser S., Baumstark MW., Gollhofer A., and König D. “Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial” British Journal of Nutrition (2015), 114, 1237–1245.

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